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地中海贫血能治愈吗?如何预防地中海贫血

发布时间:2016-05-09   问大夫  责任编辑:红豆

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地中海贫血是一组遗传性小细胞性溶血性贫血,多表现为慢性进行性溶血性贫血。可能大多数人对地中海贫血不太了解,下面就跟小编一起来看看吧。

地中海贫血的类型

根据血红蛋白中不同位置的损害可分成两类:α地中海贫血与β地中海贫血。α地中海贫血是血红蛋白中的α血红蛋白链有缺损,β地中海贫血则是血红蛋白中的β血红蛋白链有缺损。镰刀型红血球疾病,又名镰刀型贫血(Sickle Cell Anemia)和地中海贫血不同的是它只发生β血红蛋白的缺陷。

1.α地中海贫血

α地中海贫血的患者会在HBA1、HBA2这两个基因发生异常。在成人造成β蛋白链过度制造,在新生儿则是γ蛋白链过多。过多的β蛋白链形成四聚物(tetramers)使红血球的携氧能力降低。

2.β地中海贫血

β地中海贫血的患者则是在第11号染色体上的HBB基因发生突变。不正常的细胞会制造过量的α蛋白链,然后结合在红血球的细胞膜上造成细胞膜损坏;若其浓度过高,则有形成有毒聚集体(aggregates)的可能。


地中海贫血的并发症

1.过量铁质积聚

长期输血会造成铁质沉积而过量铁质的积聚会对多个器官造成破坏。主要受影响的包括心脏、肝脏、胰脏和各个内分泌器官。病者会出现心脏衰竭、肝硬化、肝功能衰退、糖尿以及因为多种内分泌失调而变得身材矮小和发育不全等等。

2.输血引起不良反应

常见输血时引起的不良反应包括发热、发冷和出红疹等。较严重的反应如急性溶血、气管收缩和血压下降等虽然甚少出现,但绝不能忽视。 在长期贫血和溶血的刺激下,不少重型和中型贫血病者都会出现脾脏发大的问题。过大脾脏会使贫血加剧和令病者需要接受更大量的输血而导致更严重的铁质积聚。 及时把发大的脾脏切除往往能令情况改善。 长期溶血令地中海贫血病人比一般人更容易患胆石。患有胆石的病人可能经常出现右上腹痛、皮肤、眼白变黄和茶色小便等的病征。

3.除铁药的副作用

除铁药会影响视力、听觉和骨骼生长。


地中海贫血能治愈吗

中西医结合治疗往往能达到好的效果,将中医治疗血液病的成功经验与西医治疗所特有的疗效快、疗程短的优势有机契合,利用生物学、免疫学、细胞学等先进理论及科技与世界较新的血液病治诊疗仪器对患者进行根本性、全方位的诊疗。以上两种方法将中西医充分融合起来,成为治疗地中海贫血的优选方法。

治疗地中海贫血,三步实现康复梦想:

1.改善造血微环境:“自血激活再生疗法”充分利用中西医的有机结合,将具有生血排毒功能的中药大分子加工处理转换为小分子,通过身体的经络和血液循环直接渗透到病灶,将细胞内毒素排出,同时激活血液细胞再生,修复受损的细胞,起到生血排毒的作用。

2.做好调节免疫:地贫患者常有免疫功能紊乱,抑制造血的负调控因子增加,止血机制异常,治疗上给予标本兼治,滋阴清热,泻火解毒,凉血止血,调整机体的免疫功能,减少造血负调控因子的产生,解除对骨髓造血的抑制。

3.通过药物修复造血干细胞:“补肾益髓技术”选用上等活性中药提纯炼制而成,富含抗氧自由基,它们能清除过多的氧自由基,使人体内自由基的生成和清除处于动态平衡中。恢复骨髓造血功能,达到造血正常。补肾益髓技术采用中药外用,减轻孩子患病医治的痛苦,同样能够收到良好的治疗效果。

地中海贫血是可以治好的,关键就在于是否能够选择正确的治疗方法。对于西医的治疗一定要慎重选择,以免给患者带来严重的副作用伤害,耽误治疗时机。


如何预防地中海贫血

1.开展人群普查和遗传咨询、作好婚前指导以避免地贫基因携带者之间联姻,对预防本病有重要意义。采用基因分析法进行产前诊断,可在妊娠早期对重型β和α地贫胎儿作出诊断并及时中止妊娠,以避免胎儿水肿综合征的发生和重型β地贫患者出生,是目前预防本病行之有效的方法。 

2.地中海型贫血带因者外表、成长与正常人无异。 

3.维他命之补充 同平常人,于医师认为必要时投予。因外表不易查觉此病,常被给予铁剂补血,应注意。 

4.婚前检查:结婚对象应检验是否为地中海型贫血带因者,若是则特别注意产前检查。 

5.产前检查:若夫妻均为带因者,每胎怀孕第12周以后即应抽取胎儿检体检,若确定为地中海型贫血重型胎儿即可予人工流产,以免将来照顾上的负担。

看了本文,你对地中海贫血有了更深的了解吧。小编希望那些地中海贫血患者,可以采用下中西医结合治疗的方法。

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